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目的：研究黄体酮、他莫西芬、潘生丁、妇复春等药物对卵巢恶性肿瘤细胞耐药的逆转作用，以及观察应用体外敏感药物及其逆转药的临床治疗疗效。方法：用改进的MTT法检测33例卵巢恶性肿瘤细胞对6种常用化疗药物敏感性及其逆转耐药作用。结果：卵巢癌药敏的顺序为Taxol>DDP>ADM>VP16>PYM>CTX；逆转药对化疗药物逆转（增敏）的顺序为黄体酮>他莫西芬>妇复春>潘生丁。使用敏感药物及其逆转药治疗后，一年以上总有效率为78.78%，其中上皮癌为78.57%。结论：选择敏感化疗药物及其逆转药使治疗个体化，可提高卵巢恶性肿瘤的疗效；黄体酮、他莫西芬可直接增强抗癌效应，并逆转化疗药耐药性，能获得更好的疗效。
Objective: To study the reversal effects of progesterone, tamoxifen, dipyridamole and fufuxin on the drug resistance of ovarian cancer cells and to observe the clinical curative effect of using in vitro sensitive drugs and their reversal agents. Methods: The sensitivities and reversal drug resistance of 33 ovarian cancer cells to 6 kinds of chemotherapeutic drugs were detected by a modified MTT assay. Results: The order of drug susceptibility of ovarian cancer was Taxol> DDP> ADM> VP16> PYM> CTX. The order of reversal (sensitization) of reversal agents to chemotherapy was progesterone> tamoxifen> Fufusun> dipyridamole. The use of sensitive drugs and their reversal drug treatment, more than one year the total effective rate was 78.78%, of which 78.57% of epithelial cancers. Conclusion: The selection of sensitive chemotherapeutic drugs and their reversal agents to individualize the treatment can improve the efficacy of ovarian cancer; progesterone and tamoxifen can directly enhance the anti-cancer effect, and reversal of chemotherapeutic drug resistance, to obtain better Efficacy.