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目的 国产乙肝基因疫苗应用时间不长 ,其免疫持久性尚不清楚。为评价国产乙肝CHO疫苗的免疫效果和免疫持久性而进行本研究。方法 应用两批国产乙肝CHO疫苗 (长春生物制品研究所生产 ) ,10 μg/剂。按 0、 1、 6程序免疫 15 0名HBVm阴性儿童 ,免疫后随访观察 5 6月。结果 全部接种儿童均无局部和全身异常反应。T7时抗—HBs阳转率均为 10 0 % ,T56时阳转率分别为 88 5 7%和 78 5 7%。结论 国产乙肝CHO疫苗有良好的安全性和免疫原性
Purpose domestic hepatitis B gene vaccine application time is not long, the immune persistence is not clear. This study was conducted to evaluate the immunogenicity and immune persistence of domestic CHO vaccine. Methods Two batches of domestic hepatitis B CHO vaccine (Changchun Institute of Biological Products) were applied at 10 μg / dose. Fifteen HBVm-negative children were immunized with 0, 1, and 6 programs. After immunization, they were followed up for 5 months. Results All vaccinated children had no local or systemic abnormal reaction. The anti-HBs positive rate was 100% at T7 and 88 57% and 78 57% respectively at T56. Conclusion Domestic CHO vaccine has good safety and immunogenicity