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目的:主要是探讨Galectin-3蛋白及P27蛋白在正常胃黏膜、不典型增生、早期胃癌进展期胃癌中的表达与临床病理特征的相关性。方法:采用免疫组织化学S-P法检测正常胃黏膜组(40例)、不典型增生组(45例)、早期胃癌组(35例)、进展期胃癌(50例)的Galectin-3、P27蛋白表达情况。结果:Galectin-3蛋白胃癌组织中阳性表达率为71.8%,在分化较高与分化较低的胃癌中的阳性率分别为72.6%和69.8%。结论:Galectin-3蛋白及P27蛋白在胃癌组织中的表达没有明显相关性,但能通过检测两者会大大提高早期胃癌早诊率,进一步提高患者生存率。
Objective: To investigate the relationship between the expression of Galectin-3 protein and P27 protein in normal gastric mucosa, atypical hyperplasia and advanced gastric cancer and its clinicopathological features. Methods: The expressions of Galectin-3 and P27 protein in normal gastric mucosa (40 cases), atypical hyperplasia group (45 cases), early gastric cancer group (35 cases) and advanced gastric cancer (50 cases) were detected by immunohistochemical SP method Happening. Results: The positive rate of Galectin-3 protein in gastric cancer tissues was 71.8%, and the positive rates of Galectin-3 protein were 72.6% and 69.8% in gastric cancer with higher differentiation and lower differentiation respectively. Conclusion: There is no significant correlation between Galectin-3 protein and P27 protein expression in gastric cancer. However, the detection of Galectin-3 protein and P27 protein can greatly improve the early diagnosis rate of gastric cancer and further improve the survival rate.