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目的:探讨幽门螺杆菌(Hp)在Hp相关性胃炎的发病机制中对胃黏膜上皮细胞解痉多肽(SP)以及细胞外信息相关蛋白激酶(ERK)表达的影响。方法:检测68例浅表性胃炎患者的活检组织标本。(1)采用免疫组织化学和染色评分的半定量法对Hp阳性组与阴性组、Hp根除前和根除后慢性浅表性胃炎患者的胃黏膜上皮细胞的SP和ERK的表达量进行检测比较。(2)采用质子泵抑制剂+克拉霉素+甲硝唑三联疗法根治Hp感染。结果:(1)Hp阳性组SP和ERK的表达量较阴性组明显减少(P<0.05)。(2)Hp根除后SP和ERK的表达量较根除前明显增加(P<0.05)。结论:SP和ERK表达量的异常在Hp致胃黏膜损害的发病机制中起重要作用。
Objective: To investigate the effect of Helicobacter pylori (Hp) on the expression of spasticity polypeptide (SP) and extracellular signal-related protein kinase (ERK) in gastric mucosal epithelial cells in the pathogenesis of Hp-related gastritis. Methods: The biopsy specimens of 68 patients with superficial gastritis were detected. (1) The expression of SP and ERK in gastric mucosal epithelial cells of Hp positive group and negative group, Hp eradication and eradication chronic superficial gastritis were detected by semi-quantitative immunohistochemistry and staining scoring. (2) Proton pump inhibitor + clarithromycin + metronidazole triple therapy to cure Hp infection. Results: (1) The expression of SP and ERK in Hp positive group was significantly lower than that in negative group (P <0.05). (2) The expression of SP and ERK after Hp eradication was significantly higher than that before eradication (P <0.05). Conclusion: Abnormal expression of SP and ERK plays an important role in the pathogenesis of gastric mucosal lesions induced by Hp.