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三联疗法根除幽门螺杆菌(Helicobacterpylori(HP),可能适用于十二指肠溃疡患者,但多数用药方案有若干缺点:铋盐不是到处可得,根除的失败与治疗前 HP 耐甲硝唑有关,且因疗程长和副作用使顺应性差。因此,需要一些不含铋剂和甲硝唑的顺应,快速和耐受良好的用药方案。Omeprazole 是一种质子泵抑制剂,因本品直接抑制 HP,通过降低胃的 pH 达到其 pKa或通过增加胃粘膜的浓度而增加抗生素(如羟氨苄青霉素)的抗菌作用。Clarithromgcin 是一种新的大环内酯抗生素,抗菌谱与红霉素相似,但更耐酸,更易吸收且胃肠道的副作用也更少。体外试验,本品对 HP 的 MIC_(90)为0.03μg/ml。本品
Triple therapy can eradicate Helicobacter pylori (HP), which may be applicable to patients with duodenal ulcer. However, most drug regimens have several disadvantages: bismuth salt is not available everywhere, and the failure of eradication is related to HP metronidazole before treatment. And due to long course of treatment and side effects so poor compliance.Therefore, the need for some non-bismuth and metronidazole compliance, rapid and well-tolerated drug program.Omeprazole is a proton pump inhibitor, because of direct inhibition of HP, Antibacterial effects of antibiotics (such as amoxicillin) are increased by lowering the pH of the stomach to its pKa or by increasing the concentration of gastric mucosa. Clarithromgcin is a new macrolide antibiotic with antibacterial spectrum similar to erythromycin but more Acid, more easily absorbed and less gastrointestinal side effects.In vitro tests, the product of HP MIC_ (90) of 0.03μg / ml. This product