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目的检测唐山地区甲状腺疾病患者的尿碘水平,分析尿碘水平与甲状腺疾病之间的相关性。方法收集本市工人医院正常成人体检者130例尿样作为对照组,同时收集5种甲状腺疾病患者尿样共285例,按病种分为5组。对所得各组的尿碘检测数据进行多组比较和两两比较。结果各甲状腺疾病组与对照组的多组比较差异有统计学意义(P<0.05)。两两比较表明,桥本氏甲状腺炎和甲状腺功能减退者与对照组比较,差异有统计学意义(P<0.05)。而甲状腺癌、甲状腺结节、毒性弥漫性甲状腺肿者的尿碘水平与对照组相比差异无统计学意义(P>0.05)。各甲状腺疾病组中均有较高比例的高碘和低碘情况存在。结论碘摄入过多可能与桥本氏甲状腺炎及甲状腺功能减退的发病有关。碘在甲状腺癌、甲状腺结节、毒性弥漫性甲状腺肿发病机制中的作用有待进一步研究。应依据个体化尿碘检测结果而不是依据病种来指导碘的摄入。
Objective To detect the level of urinary iodine in patients with thyroid diseases in Tangshan area and analyze the correlation between urinary iodine levels and thyroid diseases. Methods A total of 130 urine samples from normal workers in our city workers’ hospital were collected as control group. A total of 285 urine samples from 5 patients with thyroid disease were collected and divided into 5 groups according to their disease types. Each group obtained urine iodine detection data for multiple comparisons and pairs of comparisons. Results There were significant differences between the thyroid disease groups and the control group (P <0.05). Comparison of each other showed that Hashimoto’s thyroiditis and hypothyroidism compared with the control group, the difference was statistically significant (P <0.05). The urinary iodine levels in thyroid cancer, thyroid nodules and toxic diffuse goiter were not significantly different from those in control group (P> 0.05). Each thyroid disease group had a high proportion of high iodine and low iodine exist. Conclusions Excessive iodine intake may be related to the pathogenesis of Hashimoto’s thyroiditis and hypothyroidism. The role of iodine in the pathogenesis of thyroid cancer, thyroid nodules, toxic diffuse goiter needs further study. Should be based on individual urine iodine test results rather than based on the disease to guide the intake of iodine.