论文部分内容阅读
在３０名志愿者中观察比较３种剂型６种制剂的头孢克肟口服人体药动学特征，各批药动学参数均值：Ｃ＿（ｍａｘ）为２．１７～２．６２μｇ／ｍ１，ＡＵＣ为２５．８～２９．５（μｇ·ｈ）／ｍ１，ｔ＿（１／２ｋｅ），为３．５０～４．４３ｈ，ＭＲＴ为７．４７～８．１５ｈ，制剂间差异无显著性，Ｔ＿（ｍａｘ）为３．４～４．６ｈ，ｔ＿（１／２ｋａ）为１．３８～２．２５ｈ，细粒剂的Ｔ＿（ｍａｘ）及ｔ＿（１／２ｋａ）较胶囊及片剂短（Ｐ＜０．０１）。表明制剂间吸收程度、达峰浓度及消除过程基本一致，而细粒剂吸收速度较胶囊及片剂快。国产与相同剂型进口制剂的体内过程一致。血浓度检测用微生物法。
In 30 volunteers, we compared the pharmacokinetics of cefixime in six formulations of three dosage forms. The average pharmacokinetic parameters of each batch were: C max 2.17 ~ 2.62 μg / m 1, AUC was 25.8 ~ 29.5 (μg · h) / m1, t_ (1 / 2ke), 3.50 ~ 4.43 h, MRT was 7.47 ~ 8.15 h, there was no significant difference between the preparations, T_ max was 3.4 ~ 4.6h, t_ (1 / 2ka) was 1.38 ~ 2.25h, T_ (max) and t_ (1 / 2ka) of capsules were shorter than capsules and tablets (P < 0.01). The results showed that the degree of absorption between the preparations, the peak concentration and the elimination process are basically the same, and the absorption rate of the granules is faster than that of the capsules and the tablets. Domestic and imported formulations of the same dosage form in vivo process. Microbiological method for the determination of blood concentration.