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本文对三种不同剂量的米非司酮作为紧急避孕药进行了比较研究.240例健康妇女被随机分配在三种剂量组:10mg、50mg和600mg.服药后有1例失败.此例为10mg组,同房与服药时间相距为84.5h.三组恶心与呕吐等副反应发生率基本相似.但对月经周期影响各不相同.剂量越小对月经周期的干扰越小.引起月经延迟(比预计月经迟≥4天),10mg、50mg和600mg三组分别为21例(28.4%),34例(42.5%)及45例(60%),平均延迟时间600mg组为9.8土11.1天,明显大于10mg和50mg组(2.3土0.8天,5.7±11.3天).同时在月经不同时相服药对月经干扰也不一样.在黄体期服药者延迟月经的例数多,天数长.以上结果提示,小剂量的米非司酮10mg与600mg米非司酮一样可以作为紧急避孕药使用,而且副反应小.但如何克服服用米非司酮作为紧急避孕药后月经的延迟仍是一个值得研究的问题.
In this article, we compared three different doses of mifepristone as an emergency contraceptive: 240 healthy women were randomized to three doses: 10 mg, 50 mg, and 600 mg, and one failed after taking the drug.10 mg Group, intercourse and medication time 84.5h.The incidence of nausea and vomiting and other side effects of three groups were similar, but the impact on the menstrual cycle are different.Dose of smaller doses on the menstrual cycle, the smaller the delay caused by menstruation (than expected Menstruation was delayed for more than 4 days), 21 cases (28.4%), 34 cases (42.5%) and 45 cases (60%) in the 10mg, 50mg and 600mg groups and 9.8 ± 11.1 days 10mg and 50mg group (2.3 soil 0.8 days, 5.7 ± 11.3 days) .At the same time menstruation taking medication on the menstrual interference is not the same .Drugs in the luteal phase delay menstruation, the number of cases, long days. The above results suggest that the small The dose of mifepristone 10mg can be used as an emergency contraceptive with 600mg of mifepristone, and the side reaction is small, but how to overcome the delay of menstruation after taking mifepristone as an emergency contraception remains a worthy issue.