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慢性粒细胞白血病(CHL)患者除有Ph易位外,一少部分病例往往出现其它附加染色体畸变。慢性急变时异常染色体占病例的75%,一般包括双Ph、+8、+19、等臂17q染色体,也包括各种易位。最近,Rubin和他的同事在3例Ph阳性CML急变期病人中识别出一种新的异常核型-t(3;21)(q26;q22)。作者又报导两例t(3;21)(q26;22)出现在Ph阳性CML慢性期的病例。病例1:女性,黑人,18岁,1982年5月出现乏力,脾大。血象:血红蛋白9.7mg%,白细胞3.72×10~(11)/L,母细胞
Chronic myeloid leukemia (CHL) patients in addition to Ph translocation, a small number of cases often appear additional additional chromosomal aberrations. Chronic acute aberrant chromosomes accounted for 75% of cases, usually including double Ph, +8, +19, and other arm 17q chromosomes, but also includes a variety of translocations. Recently, Rubin and colleagues identified a new abnormal karyotype-t (3; 21) (q26; q22) in 3 Ph positive CML patients. The authors report two cases of t (3; 21) (q26; 22) occurring in Ph-positive chronic phase of CML. Case 1: Female, black, 18 years old, May 1982, fatigue, splenomegaly. Blood: hemoglobin 9.7mg%, white blood cells 3.72 × 10 ~ (11) / L, blast cells