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目的掌握广州铁路中老年职工(年龄≥45岁)脂肪肝(FLD)的流行特征及影响因素。方法2007年9月-2008年8月,选择广州铁路地区中老年职工进行问卷调查、体格检查、血生化和肝脏超声检查。结果4974例受检人员中,共检出FLD患者1473人,FLD患病率为29.6%,男性FLD患病率为29.4%,女性为30.3%,差异无统计学意义(P=0.514);男性及女性均在55～65岁达到峰值。55岁以前男性的患病率高于女性(P=0.028),55岁后两者患病率差异无统计学意义(P>0.05);酒精性脂肪肝患病率为5.4%,非酒精性脂肪肝(NAFLD)患病率为24.2%;多因素Logistic回归分析显示饮酒、高血压、高甘油三酯、高血糖、肥胖、高尿酸血症是广州铁路中老年职工FLD的影响因素。结论广州铁路中老年职工FLD患病率高,主要为NAFLD。饮酒、高血压、高甘油三酯、高血糖、肥胖、高血尿酸等为FLD的影响因素。
Objective To understand the prevalence and influential factors of fatty liver (FLD) among middle-aged and elderly workers (aged 45 years and above) in Guangzhou Railway. Methods From September 2007 to August 2008, questionnaires, physical examination, blood biochemistry and liver ultrasonography were performed on middle-aged and elderly workers in Guangzhou Railway. Results Among the 4974 subjects tested, 1473 FLD patients were detected, the prevalence of FLD was 29.6%, the prevalence of FLD was 29.4% in males and 30.3% in females, with no significant difference (P = 0.514); males And women reached the peak in 55 to 65 years old. The prevalence rate of male before 55 was higher than that of female (P = 0.028), but there was no significant difference after 55 years old (P> 0.05). The prevalence of alcoholic fatty liver was 5.4% The prevalence of fatty liver (NAFLD) was 24.2%. Multivariate Logistic regression analysis showed that alcohol, hypertension, triglyceride, hyperglycemia, obesity and hyperuricemia were the influencing factors of FLD in Guangzhou Railway middle-aged and elderly workers. Conclusion The prevalence of FLD in middle-aged and elderly workers in Guangzhou Railway is high, mainly NAFLD. Alcohol consumption, high blood pressure, high triglycerides, hyperglycemia, obesity, hyperuricemia and other factors for the FLD.