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许多体外和体内的研究表明,Ca~(++)在胰岛素释放过程中起着极重要的作用。因此,不难理解甲状旁腺激素分泌异常的各种继发性慢性钙代谢紊乱,如甲状旁腺机能减退或亢进,会明显地影响胰岛紊的分泌。已有报告降钙素在人体有致糖尿病作用。在正常人、肥胖者及糖尿病前期患者快速给予降钙素可抑制由葡萄糖刺激所致的胰岛素分泌,并妨碍静脉注射的葡萄糖的利用。本文报道,在正常人、葡萄糖耐量减低(IGT)患者肌注降钙素对口服葡萄糖耐量(OGTT)、血浆胰岛素、C 肽、高血糖素和生长激素浓度的影响。16名受试者中,8名(男3,女5,25～45岁)
Many in vitro and in vivo studies have shown that Ca ~ (++) plays an important role in the insulin release process. Therefore, it is not difficult to understand the abnormal parathyroid hormone secretion of various secondary chronic calcium metabolic disorders, such as hypoparathyroidism or hyperthyroidism, will significantly affect the secretion of pancreatic islet disorders. Calcitonin has been reported to cause diabetes in humans. The rapid administration of calcitonin in normal, obese and pre-diabetic patients suppresses insulin secretion stimulated by glucose and hinders the utilization of intravenous glucose. This article reports the effects of intramuscular calcitonin on oral glucose tolerance (OGTT), plasma insulin, C-peptide, glucagon, and growth hormone levels in normal, impaired glucose tolerance (IGT) patients. Of the 16 subjects, 8 (male 3, female 5, 25-45)