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一般认为抗核抗体既无器官特异性,也无种族特异性。然而近几年来,曾报告它有一定限度的特异性。据报道有一种只与粒细胞核抗原起反应的自身抗体,它是类风湿关节炎所特有的。作者通过免疫荧光技术,三年来检测血清23000份,抗核抗体阳性者3450份,发现23份(0.66%)血清里存在一种与人细胞核抗原发生反应的自身抗体。这种自身抗体和鼠肾、鼠肝细胞核反应很弱或不反应。23份血清中只有7份血清可与其它物种细胞核发生弱反应,滴度在1:80以下,这种弱阳性反应,能被丙酮提取的兔胸腺粉吸收而消失。但与人细胞核的反应,既使在低滴度抗
Anti-nuclear antibodies are generally considered neither organ-specific nor racially specific. However, in recent years, it has been reported that it has a certain degree of specificity. It has been reported that there is an autoantibody that reacts only with granulocyte nuclear antigen, which is peculiar to rheumatoid arthritis. By means of immunofluorescence, 23,000 sera and 3450 antinuclear antibodies were detected in three years and 23 (0.66%) sera were found to have autoantibodies that react with human nuclear antigens. This autoantibody and rat kidney, rat hepatocyte nuclear reaction is weak or not. Only 7 of the 23 serums reacted weakly to the nucleus of other species with a titer below 1:80. This weakly positive reaction was abolished by the absorption of acetone-extracted rabbit thymus meal. But the reaction with the human nucleus, even in low titers