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目的:探讨多囊卵巢综合征(polycystic ovary syndrome,PCOS)患者糖、脂代谢特征及身体脂肪分布特点。方法:选取多囊卵巢综合征患者31例,肥胖组(Ob-PCOS)17例,非肥胖组(Nob-PCOS)14例及年龄相匹配正常生育年龄妇女64例为对照组,进行生殖内分泌、糖、脂代谢指标检测,并采用双能X线吸收仪(DXA)测量全身和局部身体成分,计算“男性”与“女性”区域脂肪百分比的比值(A/G)。结果:肥胖组PCOS患者睾酮(T)、空腹胰岛素(Ins)、胰岛素敏感指数(ISI)、甘油三酯(TG)高于非肥胖PCOS组、对照组(P<0.01),差异有统计学意义,非肥胖PCOS组ISI、血糖高于对照组(P<0.01),差异有统计学意义。对照组HDL高于PCOS组(P<0.01),差异有统计学意义。PCOS组男性脂肪量、A/G高于对照组,差异有统计学意义(P<0.01),PCOS组间亦有差异。男性脂肪量与ISI成负相关(r分别-0.672,P<0.01)。结论:①PCOS组糖、脂代谢存在异常,存在胰岛素抵抗,肥胖组更加明显;②PCOS组脂肪分布呈男性脂肪分布模式,男性脂肪量与胰岛素抵抗有相关性。
Objective: To investigate the characteristics of glucose and lipid metabolism and body fat distribution in patients with polycystic ovary syndrome (PCOS). Methods: Thirty-one patients with polycystic ovary syndrome, 17 obesity patients (Ob-PCOS), 14 non-obese patients (Nob-PCOS) and 64 healthy women of normal reproductive age were selected as control group, (A / G) ratio of fat in the “male” and “female” regions were calculated by measuring whole body and local body composition using dual energy X-ray absorptiometry (DXA). Results: The levels of testosterone, Ins, ISI and triglyceride in obese patients with PCOS were significantly higher than those in non-obese PCOS patients and control patients (P <0.01) , Non-obese PCOS group ISI, blood glucose higher than the control group (P <0.01), the difference was statistically significant. HDL in control group was higher than that in PCOS group (P <0.01), the difference was statistically significant. The level of AOB in male PCOS group was higher than that in control group (P <0.01). PCOS group also had differences. Male fat mass was negatively correlated with ISI (r = -0.672, P <0.01, respectively). Conclusion: ①PCOS group, abnormal glucose metabolism, there is insulin resistance, obesity group more obvious; ②PCOS fat distribution was male fat distribution pattern, male fat mass and insulin resistance are related.