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端粒是真核细胞染色体末端的特殊结构,由简单的串联重复DNA序列组成,称作细胞衰老的生物钟。端粒长度不断发生动态变化,随年龄增大而进行性缩短,触发血管内皮/平滑肌细胞的老化及功能障碍,导致血管壁修复能力下降,促进动脉粥样硬化斑块的病理演进和不稳定,最终引发冠心病、脑卒中。另外,端粒长度也与某些心血管病的危险因素如肥胖、高血压等密切相关。本文就端粒损耗与心血管病及其危险因素之间的关系进行综述。
Telomeres are a special structure at the end of the chromosome of eukaryotes and consist of simple tandem repeated DNA sequences called the biological aging of cells. Telomere length changes dynamically, with the age of shortening, triggering the aging of vascular endothelial cells / smooth muscle cells and dysfunction, resulting in decreased ability to repair the vessel wall and promote the pathological evolution of atherosclerotic plaque and instability, Eventually lead to coronary heart disease, stroke. In addition, telomere length is also associated with certain cardiovascular risk factors such as obesity and high blood pressure. This article reviews the relationship between telomere loss and cardiovascular disease and its risk factors.