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目的:了解某医学院校不同性别和年级的临床医学硕士专业学位研究生(以下简称专硕)焦虑、抑郁水平，查找其影响因素。方法:本研究采用问卷调查方法。2019年6月～2019年8月初，采用Zung编制的焦虑自评量表(Self-Rating Anxiety Scale，SAS)和抑郁自评量表(Self-Rating Depression Scale，SDS)对1 286名专硕(参加住院医师规范化培训的研究生)进行问卷调查。结果:专硕SAS得分高于国内常模[(45.91±11.36)比(29.78±6.46 )，n P<0.01]; SDS得分高于国内常模[(49.84±13.07)比(33.46±8.55)，n P<0.01]；女研究生患有焦虑抑郁的风险是男研究生的1.775倍(n OR＝1.775，95%n CI：1.250～2.520)；有导师科研压力的专硕患有焦虑抑郁的风险是无导师科研压力专硕的1.525倍(n OR＝1.525，95%n CI：1.007～2.329)；睡眠不足专硕患有焦虑抑郁的风险是睡眠充足专硕的1.614倍(n OR＝1.614，95%n CI：1.109～2.350)。n 结论:某医学院校专硕焦虑、抑郁水平均高于国内常模；导师科研压力、睡眠不足是促使专硕焦虑伴随抑郁发生的危险因素。要及时关注和干预专硕焦虑和抑郁问题，以提高专硕的心理健康水平。“,”Objective:To understand the anxiety and depression levels of professional master degree(PMD) of clinical medicine in clinical medicine in a medical college, and to find the influencing factors.Methods:1 286 PMD were surveyed by SAS and SDS, which were compiled by Zung from June to August 2019.Results:The SAS score of PMD was higher than that of national norm (45.91±11.36) vs(29.78±6.46), n P<0.01; and the SDS score of PMD was higher than that of national norm (49.84±13.07) vs(33.46±8.55),n P<0.01. Female PMD are 1.775 times more likely to suffer from anxiety and depression than male PMD (n OR=1.775, 95%n CI: 1.250 ~ 2.520). The risk of anxiety and depression was 1.525 times (n OR=1.525, 95%n CI: 1.007 ~ 2.329) for PMD with research pressure from supervisors. The risk of anxiety and depression was 1.614 times that of the sleep-deprived PMD (n OR=1.614, 95%n CI: 1.109~2.350).n Conclusions:The level of anxiety and depression of PMD is higher than that in national norm. Supervisor research pressure and insufficient sleep are the risk factors of anxiety and depression of for PMD. To improve the mental health of PMD, it should be paid attention to and intervene the anxiety and depression.