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目的观察不同剂量洛伐他汀治疗冠心病合并高脂血症患者的临床疗效。方法选择我院2011年3月-2012年3月78例冠心病合并高脂血症患者随机分为两组,A组39例患者给予常规剂量口服20mg/d洛伐他汀治疗,B组39例患者在A组常规剂量的基础上增加10mg/d洛伐他汀治疗,观察两组患者于治疗前后血脂指标变化情况及不良反应。结果两组治疗后血脂各指标与治疗前比较差异具有显著性,B组治疗效果明显好于A组,两组比较差异具有显著性,有统计学意义(P<0.05)。B组治疗8周后TC达标28例,达标率为71.79%,LDL-C达标31例,达标率为79.49%,与A组比较差异具有显著性,有统计学意义(P<0.05)。A组出现不良反应3例,不良反应率7.69%,B组不良反应5例,不良反应率12.82%,均为轻度腹泻,两组不良反应比较差异无显著性,无统计学意义(P>0.05)。结论不同剂量洛伐他汀治疗冠心病合并高脂血症的临床疗效有很大的差别,增大洛伐他汀剂量治疗后患者各方面指标均好于常规洛伐他汀剂量治疗,且增大剂量后无明显不良反应,建议临床治疗时可提高洛伐他汀剂量,以提高治疗效果。
Objective To observe the clinical effects of different doses of lovastatin on patients with coronary heart disease complicated with hyperlipidemia. Methods A total of 78 patients with coronary heart disease complicated with hyperlipidemia in our hospital from March 2011 to March 2012 were randomly divided into two groups: 39 patients in group A were given lovastatin 20 mg / d orally and 39 patients in group B Patients in the A group conventional dose based on the addition of lovastatin 10mg / d treatment, two groups of patients before and after treatment to observe changes in blood lipid levels and adverse reactions. Results After treatment, the indexes of blood lipids in both groups were significantly different from those before treatment. The treatment effect in group B was significantly better than that in group A, with significant difference between the two groups (P <0.05). After 8 weeks of treatment, TC in 28 cases reached a standard of 28 cases, with the compliance rate of 71.79% and 31 cases of LDL-C reaching the standard of 79.49%. There was significant difference between the two groups (P <0.05). A group of adverse reactions occurred in 3 cases, the adverse reaction rate was 7.69%, 5 cases of adverse reactions in group B, the adverse reaction rate was 12.82%, were mild diarrhea, the two groups showed no significant difference in adverse reactions, no statistical significance (P> 0.05). Conclusions The clinical effects of different doses of lovastatin on patients with coronary heart disease complicated with hyperlipidemia are very different. Increasing the dosages of lovastatin after treatment in all aspects of patients is better than the conventional lovastatin dose treatment, and after increasing the dose No significant adverse reactions, it is recommended to increase the dose of lovastatin during clinical treatment to improve the therapeutic effect.