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目的研究辛伐他汀对肾移植术后高脂血症患者的疗效。方法17例肾移植术后患者每日口服辛伐他汀10mg,持续时间1个月。口服辛伐他汀前后患者自肘静脉采血 ,以标准酶法在自动生化分析仪上测定血浆总胆固醇、甘油三酯浓度 ,并以特异性荧光偏振免疫法测定环孢素全血药物浓度。结果17例肾移植术后患者在口服辛伐他汀每日10mg 一个月后 ,血浆总胆固醇水平从8.47±2.18mmol/L显著降至7.59±3.28mmol/L(P<0.05),而甘油三酯水平基本不变 ,环孢素全血浓度从185.31±39.02ng/ml显著升高至257.33±57.78ng/ml(P<0.01),在口服辛伐他汀的21例患者无1例观察到严重药物不良反应。结论小剂量的辛伐他汀能有效且比较安全地用于肾移植术后高脂血症患者
Objective To study the effect of simvastatin on patients with hyperlipemia after renal transplantation. Methods 17 cases of renal transplantation patients daily oral simvastatin 10mg, duration 1 month. Before and after oral administration of simvastatin, blood samples were drawn from the vein of the elbow, and plasma total cholesterol and triglyceride concentrations were measured by the standard enzymatic method on an automatic biochemical analyzer. Cyclosporine whole blood drug concentration was determined by specific fluorescence polarization immunoassay. Results After 17 months of renal transplantation, the total plasma cholesterol level decreased significantly from 8.47 ± 2.18mmol / L to 7.59 ± 3.28mmol / L (P <0.05) after oral administration of simvastatin 10mg daily, while triglyceride The level of ciclosporin was significantly increased from 185.31 ± 39.02ng / ml to 257.33 ± 57.78ng / ml (P <0.01). No severe drug was observed in 21 of the 21 patients receiving simvastatin Adverse reactions. Conclusion Low-dose simvastatin can be used effectively and safely in patients with hyperlipemia after renal transplantation