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目的:观察急性冠脉综合征(ACS)病人的病程、预后与焦虑和/或抑郁状态的相关因素及临床干预研究。方法:选自2006-01~2009-07包钢三医院心内科急性冠脉综合征伴焦虑抑郁住院病人139例。根据诊断分为UAP组和AM I组,采用心理CT分析系统进行诊断分析,组内随机分为治疗组和对照组,对治疗组进行临床心理干预治疗同时及药物治疗,给予阿普唑仑0.4mg(1-1-2)口服(早、午各服一片,晚服二片),或阿普唑仑(剂量同前)+文拉法辛75mg/d口服,疗程10d。对照组仅给予药物治疗。结果:相应临床干预对其认知行为、hs-CRP、心率变异性、睡眠障碍、住院天数、重返工作等情况具有明显影响。结论:ACS病人是否伴有焦虑和/或抑郁状态与自身多因素相关,相应干预对该类病人病程、预后产生积极的作用。
Objective: To observe the related factors and clinical intervention of acute coronary syndrome (ACS) patients’ course of disease, prognosis and anxiety and / or depression. Methods: A total of 139 inpatients with acute coronary syndrome and anxiety and depression in the Department of Cardiology of Baosteel Third Hospital from January 2006 to July 2009 were enrolled. According to the diagnosis, the patients were divided into UAP group and AMI group. The patients were divided into treatment group and control group by using the psycho-CT analysis system. The patients in the treatment group were treated with clinical psychological intervention and drug treatment. Alprazolam 0.4 mg (1-1-2) orally (morning and afternoon each serving a tablet, two night service), or alprazolam (with the same dose) + venlafaxine 75mg / d orally for 10d. Control group only given drug treatment. Results: The corresponding clinical intervention had significant effects on cognitive behavior, hs-CRP, heart rate variability, sleep disorders, hospitalization days, return to work and so on. Conclusion: Whether ACS patients with anxiety and / or depression is related to their own multiple factors, the corresponding interventions have a positive effect on the course and prognosis of these patients.