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目的 探讨二硫化碳 (CS2 )接触工人尿 2 硫代噻唑烷 4 羧酸 (TTCA)的排泄规律 ,为制定CS2 短时接触生物监测提供实验依据。方法 将受试对象分为 3组进行实验 :(1) 14名非CS2 接触者在某CS2 车间暴露 2h后收集不同时段尿液 ,分析其TTCA浓度变化 ;(2 )某CS2 车间 15名CS2 接触工人三班倒休息 4 8h后上班 ,连续收集 3d班前、班中、班末尿 ,分析其TTCA浓度变化 ;(3)收集 4 0名长期接触CS2 工人班末尿 ,分析其TTCA浓度变化与工人接触CS2 的 8h时间加权平均浓度 (PC TWA)的关系。结果 第 1组研究结果显示 ,接触CS2 4h后 (此时已停止接触 2h)尿中TTCA含量达到最高值 [(1.0 3± 0 .72 )mg/gCr];第 2组研究结果显示 ,班前尿TTCA含量极低 [(0 .37± 0 .2 8)mg/gCr],与班中尿 [上班后 4h(1.2 3± 0 .71)mg/gCr]及班末尿 [(1.31± 0 .78)mg/gCr]比较 ,差异有显著性 (P <0 .0 1) ,而班中尿TTCA值与班末尿相比 ,差异无显著性 (P >0 .0 5 ) ;第 3组研究结果显示 ,班末尿TTCA值与工人PC TWA之间有直线关系 [Y(TTCAmg/gCr) =1.16 36X(CS2 mg/m3) - 5 .4 116 ]。结论 班末尿TTCA值可作为CS2 接触工人的生物监测指标。
Objective To investigate the excretion of urinary 2-thio-thiazolidine-4-carboxylic acid (TTCA) in workers exposed to carbon disulfide (CS2) and to provide experimental evidence for the development of biological monitoring of short-term exposure to CS2. Methods The subjects were divided into three groups to conduct experiments: (1) 14 non-CS2 contacts were collected in a CS2 workshop 2h after the collection of urine at different time points, analysis of its TTCA concentration changes; (2) a CS2 workshop 15 CS2 exposure (3) 40 urinary excretion of CS2 workers who were exposed to CS2 for a long time were analyzed, and their TTCA concentration changes were analyzed with Workers exposed to CS2 8h time weighted average concentration (PC TWA) relationship. Results The results of the first study showed that the TTCA content in urine reached the highest value (1.03 ± 0.72 mg mg / gCr) after 4 hours of CS2 exposure (at this time, the contact was stopped for 2 hours). The results of the second group showed that before the class Urinary TTCA was significantly lower in urine ([0.37 ± 0.28 (mg / gCr]] and urine in urine [4h after operation (1.2 3 ± 0.71) mg / gCr] .78) mg / gCr], the difference was significant (P <0. 01), while the urinary TTCA value in the class had no significant difference (P> 0.05) The group study showed a linear relationship between the TTCA value at the end of the shift and the worker PC TWA [Y (TTCAmg / gCr) = 1.16 36X (CS2 mg / m3) - 5.4116]. Conclusions The TTCA value of the end-stage urine can be used as a biological monitoring indicator of CS2 exposed workers.