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增加药物用量可延长药物的作用时间,但有增加毒副作用的危险。长效制剂的品种有限,远不能适应临床需要。近年来,为了延长药物作用时间,在药代动力学和高分子科学(化学)发展的基础上,各国普遍地对给药系统进行了开发,如: 1.缓释制剂:通过降低药物溶解性或将其置于坚固难溶胶丸中,服后缓慢释放而延长作用时间,但生效太慢。 2.自动泵:将储药(如胰岛素)微泵或特制渗透泵胶囊植入皮下,通过高效电池
Increase the amount of drugs can extend the duration of the drug, but there is an increased risk of toxic side effects. Long-acting formulations of a limited variety far can not meet the clinical needs. In recent years, drug delivery systems have been widely developed in the fields of pharmacokinetics and macromolecular science (chemistry) in order to prolong the action time of drugs, such as: 1. Sustained release formulations: By reducing drug solubility Or place it in a firm and hard capsule, slow release after service to extend the action time, but the effect is too slow. 2 automatic pump: the medicine (such as insulin) micro pump or special osmotic pump capsule subcutaneously, through the high efficiency battery