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局部脑皮层发育不良(focal cortical dysplasia,FCD)是皮质发育畸形的一个亚型,其下又有众多分类方法,最常用的是Palmini和Tassi等提出的2种根据组织病理学的分类系统。FCD与胚胎发育早期神经元的增殖、移行、组织等过程密切相关,并且有许多基因和蛋白包括细胞骨架系统相关蛋白、多耐药基因和多耐药蛋白转运体等,均参与了FCD异常细胞的发生,诱发癫痫和导致了癫痫的难治性。目前对FCD引起的药物难治性癫痫无特殊的治疗方法,可以首先尝试使用抗局灶癫痫的药物治疗,其次再考虑行局部病灶的手术切除。根据目前资料,尚不能正确估计两种治疗的预后情况。
Focal cortical dysplasia (FCD) is a subtype of cortical developmental deformity. There are many other classification methods, the most commonly used is the classification system based on histopathology proposed by Palmini and Tassi et al. FCD is closely related to the process of proliferation, migration and organization of neurons in early embryonic development, and many genes and proteins including cytoskeleton system related proteins, multidrug resistance genes and multidrug resistance protein transporters are involved in FCD abnormal cells The occurrence of epilepsy and lead to epilepsy refractory. FCD-induced drug-refractory epilepsy no special treatment, you can first try to use anti-focal epilepsy drug treatment, and then consider the line of local lesion surgery. Based on the current information, the prognosis of the two treatments can not yet be correctly estimated.