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目的 探讨不同剂量国产米非司酮用于紧急避孕的临床疗效。方法 6年内对 40 0余名要求紧急避孕者 ,分别给予不同剂量的米非司酮片 10 0mg、 5 0mg、 40mg、 2 0mg、 10mg ,观察紧急避孕效果 ,药物副反应 ,月经复潮情况。结果 避孕有效率的 95 %可信区间分别为 10 0mg组 84 11%～ 96 95 % ,5 0mg组 93%～ 10 0 % ,40mg、2 0mg、 10mg组均为 88%～ 10 0 %。药物副反应发生率分别为 2 4%、 18%、 10 %、 6 %、 3%。结论 米非司酮用于紧急避孕临床观察效果满意 ,研究剂量范围内 10mg即可达到满意的紧急避孕效果 ,药物副反应发生率随着用药剂量的增加而升高
Objective To investigate the clinical efficacy of different doses of domestic mifepristone for emergency contraception. Methods A total of 40 0 emergency contraception recipients were given different doses of mifepristone tablets in 10 years, 50 mg, 40 mg, 20 mg and 10 mg respectively. The effects of emergency contraception, side effects of drugs and tide of menstruation were observed. Results The 95% confidence intervals for effective contraception were 84 11% to 96 95% for the 10 0 mg group and 93% to 100% for the 50 mg group, respectively, and 88% to 100% for the 40 mg, 20 mg and 10 mg groups. Side effects of drugs were 24%, 18%, 10%, 6%, 3%. Conclusions Mifepristone is satisfactory for clinical observation of emergency contraception, and satisfactory emergency contraception can be achieved within the range of 10 mg. The incidence of side effects of the drug increases with the increase of the dose of mifepristone