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对菊科蚂蚱腿子属植物万花木Myripnois dioica地上部分的化学成分进行研究。利用多种色谱技术从万花木95%乙醇提取物中分离得到12个化合物;通过理化性质和波谱数据分别鉴定为8-desoxyurospermal A(1),zaluzanin C(2),dehydrozaluzanin C(3),glucozaluzanin C(4),macrocliniside B(5),macrocliniside I(6),taraxinic acid-14-O-β-D-glucopyranoside(7),ainsliaside B(8),洋芹素(9),木犀草素(10),洋芹素-7-O-β-D-吡喃葡萄糖苷(11)和木犀草素-7-O-β-D-吡喃葡萄糖苷(12)。除化合物8以外,其他化合物均为首次从该属植物中分离得到。对化合物8的降血糖活性进行了研究,结果表明化合物8可较好地降低四氧嘧啶所致糖尿病小鼠的血糖水平。
The chemical composition of the aboveground part of Myripnois dioica, a member of Compositae genus Lepidoptera, was studied. Twelve compounds were isolated from 95% ethanol extracts of Mucuna trees by using a variety of chromatographic techniques. Their chemical and physical properties were identified as 8-desoxyurospermal A (1), zaluzanin C (2), dehydrozaluzanin C (3), glucozaluzanin (4), macrocliniside B (5), macrocliniside I (6), taraxinic acid-14-O-β-D-glucopyranoside (7), ainsliaside B 10), oiliferin-7-O-β-D-glucopyranoside (11) and luteolin-7-O-β-D-glucopyranoside (12). Except for compound 8, all the other compounds were isolated from this genus for the first time. The hypoglycemic activity of Compound 8 was studied. The results showed that Compound 8 can reduce the blood glucose level of alloxan-induced diabetic mice.