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目的探讨纳美芬联合高压氧治疗急性一氧化碳中毒的临床疗效.方法收治急性一氧化碳中毒患者70例,随机分为对照组、治疗组各35例.对照组给予对症支持治疗及高压氧治疗,治疗组在对照组的基础上给予纳美芬治疗观察两组临床疗效.结果对照组的总有效率77.14﹪,治疗组的总有效率97.14﹪,两组比较差异具有统计学意义(P<0.05);治疗组的平均昏迷时间和迟发性脑病发生率及病死率与对照组比较差异具有统计学意义(P<0.05).结论纳美芬联合高压氧治疗急性一氧化碳中毒疗效显著,能明显缩短患者昏迷时间,减少迟发性脑病的发生率及病死率.“,”Objective To investigate therapeutic effect of nalmefene combined with hyperbaric oxygen curing acute carbon monoxide poisoning. Methods 70 patients were divided into control group35 and treatment group35 random. Control group were treated with supportive and hyperbaric oxygen treatment, treatment group were treated with nalmefene in addition and observe the clinical therapeutic effect. Results Total effective rate of both control group and treatment group are 77.14﹪ and 97.14﹪,the difference between two groups has statistical significance(P<0.05), The average duration of coma and incidence rate of delayed encephalopathy of treatment group has statistical significance compared with control group(P<0.05). Results Nalmefene combined with hyperbaric oxygen to cure acute carbon monoxide poisoning has significant.It can obviously shorten coma duration, reducing incidence rate and case fatality rate of delayed encephalopathy.