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吡喹酮,国外名 Praziguantel 或 Biltricide,代号 EMBAY 8440,是西德拜耳和伊默克两药厂合成的一种广谱抗蠕虫病新药。从1975年起,国外学者相继报道了其抗绦虫的幼虫及成虫、人体四种血吸虫(日本、埃及、曼氏与间插血吸虫)及华支睾吸虫的作用。国内已于1977年底由中国医学科学院寄生虫病研究所仿制成功。经动物实验与临床观察,证明吡喹酮对日本血吸虫、华支睾吸虫、肺吸虫与姜片虫有良好效果,对囊虫(猪囊尾蚴)、包虫(棘球蚴)亦有一定效果。鉴于该药具有疗效高、毒性低、疗程短、使用方便及适用范围广等优点,目前一致认为是一个良好的抗蠕虫病新药。
Praziquantel, a foreign name Praziguantel or Biltricide, code-named EMBAY 8440, is a new broad-spectrum anthelmintic drug synthesized by West Bayer and Emerson Pharmaceuticals. Since 1975, foreign scholars have successively reported the effects of their larvae and adults against Taenia saginata, the four human schistosomiasis (Japan, Egypt, Man and Schistosoma japonicum), and Clonorchis sinensis. The country was successfully imitated by the Institute of Parasitic Diseases, Chinese Academy of Medical Sciences by the end of 1977. Animal experiments and clinical observation showed that praziquantel had good effects on Schistosoma japonicum, Clonorchis sinensis, paragonimiasis and zooxanthellae and also had some effects on cysticercosis (Cysticercus cellulosae) and hydatid (echinococcus) . In view of the drug has the advantages of high efficacy, low toxicity, short course of treatment, easy to use and wide range of applications, is currently considered a good new anti-helminths medicine.