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非酒精性脂肪肝(NAFLD)是一种无过量饮酒史的以肝实质细胞脂肪变性和脂肪贮积为特征的临床病理综合征。其发病机制至今仍尚不清楚。最为接受的理论是Day和James等提出的“二次打击”学说。最早时认为“第1次打击”是脂肪积聚和脂肪变性,“第2次打击”是指氧应激和异常的细胞因
Non-alcoholic fatty liver (NAFLD) is a clinical pathological syndrome characterized by fatty liver hepatocyte steatosis and fat accumulation without excessive alcohol consumption. Its pathogenesis is still not clear. The most accepted theory is the “second strike” doctrine proposed by Day and James. The earliest thought that “the first strike” is fat accumulation and steatosis, “the second strike” refers to oxygen stress and abnormal cytokine