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目的:探讨布拉氏酵母菌佐治儿童细菌性肠炎中的临床疗效。方法:以湖北省医药学院附属人民医院2010年9月至2011年12月收治的98例细菌性肠炎患儿为研究对象,随机分成治疗组和对照组各49例。两组均给予抗感染、补液、对症治疗,治疗组在上述治疗的基础上同时口服布拉氏酵母菌散剂250 mg,每天2次治疗至治愈出院,比较两组症状体征恢复情况及临床疗效,观察不良反应。结果:治疗组总有效率100.0%,对照组总有效率88.6%,两组比较差异有统计学意义(P<0.05)。腹泻平均持续时间分别为治疗组(5.9±1.1)d,对照组(7.9±1.8)d,两组比较差异有统计学意义(P<0.05);入院后第5天平均大便次数比较,治疗组(2.5±0.8)次,对照组(3.9±1.2)次,第7天平均大便次数分别为治疗组(1.2±0.4)次,对照组(2.3±0.8)次,两组比较差异均有统计学意义(P<0.01)。结论:布拉氏酵母菌可缩短儿童细菌性肠炎的腹泻持续时间,减少腹泻次数。
Objective: To investigate the clinical efficacy of brucella yeast in children with bacterial enteritis. Methods: Ninety-eight children with bacterial enteritis admitted to the People’s Hospital of Hubei Province from September 2010 to December 2011 were randomly divided into treatment group (49 cases) and control group (49 cases). The two groups were given anti-infective, rehydration, symptomatic treatment, the treatment group oral administration of Saccharomyces boulardii 250 mg at the same time, twice a day to cure and discharge, the recovery of symptoms and signs and clinical efficacy, Adverse reactions observed. Results: The total effective rate was 100.0% in the treatment group and 88.6% in the control group, with significant difference between the two groups (P <0.05). The mean duration of diarrhea was 5.9 ± 1.1 days in the treatment group and 7.9 ± 1.8 days in the control group, respectively. The difference between the two groups was statistically significant (P <0.05) (2.5 ± 0.8), control group (3.9 ± 1.2) times, the average stool frequency on the seventh day were 1.2 ± 0.4 times in the treatment group and 2.3 ± 0.8 times in the control group, the differences between the two groups were statistically significant Significance (P <0.01). Conclusion: Brachyspira can shorten the duration of diarrhea in children with bacterial enteritis and reduce the frequency of diarrhea.