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本文作者评价了在结节病和其他肉芽肿性疾病中血清血管紧张素转化酶(SACE)测定的特异性和用类固醇治疗对酶活力的影响。经组织学证实为急性结节病24例,慢性结节病66例,其他肉芽肿性疾病包括结核病22例、麻疯病20例、原发性胆汁性肝硬化31例、炎症性肠疾病26例、肉芽肿性肝炎8例、何杰金氏病5例和血吸虫病2例。并以80例胸片正常健康人为对照。SACE采用分光荧光测量法测定。 80例对照血清平均酶活力为34±9u(正常范围16～52u)。24例急性结节病患者酶活力为59±23u;66例慢性结节病为50±23u。急性或慢性结节病患者和对照组之间的平均差异具有显著意义(P<0.001)。未接受类固醇治疗的60例结节病患者平均酶活力为58±24u,而类固醇治疗的30例患者酶活力为40±19u(P<0.001)。
The authors evaluated the specificity of the serum ACE assay (SACE) in sarcoidosis and other granulomatous diseases and the effect of steroid treatment on enzyme activity. Histologically confirmed as acute sarcoidosis in 24 cases, 66 cases of chronic sarcoidosis, other granulomatous diseases including tuberculosis in 22 cases, 20 cases of leprosy, 31 cases of primary biliary cirrhosis, inflammatory bowel disease 26 For example, 8 cases of granulomatous hepatitis, 5 cases of Hodgkin’s disease and 2 cases of schistosomiasis. And 80 cases of normal healthy people as control. SACE was measured by spectrofluorometry. The average enzyme activity of 80 control serum was 34 ± 9u (normal range 16 ~ 52u). 24 cases of acute sarcoidosis enzyme activity was 59 ± 23u; 66 cases of chronic sarcoidosis 50 ± 23u. The mean difference between patients with acute or chronic sarcoidosis and controls was significant (P <0.001). The mean enzyme activity of 60 patients with sarcoidosis who did not receive steroid therapy was 58 ± 24 u, while the enzyme activity of the 30 patients treated with steroids was 40 ± 19 u (P <0.001).