论文部分内容阅读
目的探讨养阴通脑颗粒中黄酮对脑缺血-再灌流损伤的保护作用。方法制作SD大鼠脑缺血-再灌流损伤模型,随机分假手术对照组、脑缺血-再灌流损伤组和黄酮组及维脑路通对照治疗组3组,观察各组脑组织前列环素(PGI2)含量、脑组织超氧化物岐化酶(SOD)活性和丙二醛(MDA)含量、血浆组织型纤溶酶原激活物(t-PA)活性及其抑制物(PAI)活性和脑组织ET-1基因表达等指标的变化。结果黄酮可显著提高脑组织PGI2含量;调节血浆t-PA与PAI的活性;显著降低脑组织MDA含量,提高脑组织SOD活性,抑制脑缺血脑皮层ET-1基因表达。结论黄酮具有抗凝、提高纤溶活性和提高细胞抗氧化等多种作用,黄酮对脑缺血-再灌流损伤具有保护作用。
Objective To investigate the protective effect of flavone in Yangyin Tongnao Granule on cerebral ischemia-reperfusion injury. Methods SD rat models of cerebral ischemia-reperfusion injury were made. Randomized sham operation control group, cerebral ischemia-reperfusion injury group and flavonoid group and Wei Nao Lutong control treatment group were used to observe the forebrain of the brain. PGI2 content, superoxide dismutase (SOD) activity and malondialdehyde (MDA) content in brain, plasma tissue plasminogen activator (t-PA) activity and its inhibitor (PAI) activity And brain tissue ET-1 gene expression and other indicators of change. Results Flavonoids can significantly increase the content of PGI2 in brain tissue, regulate the activity of plasma t-PA and PAI, significantly reduce the content of MDA in brain tissue, increase the activity of SOD in brain tissue, and inhibit the expression of ET-1 gene in cerebral ischemic cortex. Conclusion Flavonoids have many effects such as anticoagulation, fibrinolytic activity and antioxidation of cells. Flavonoids have protective effects on cerebral ischemia-reperfusion injury.