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目的：探讨健康成人肺ＣＯ弥散量（ＤＬＣＯ）正常值及预计回归方程式及其临床应用。方法：用６２００ＡｕｔｏｂｏｘＤＬ型体积描记仪测定了１７５例健康成人，２４例支气管哮喘，１９例肺间质性病变患者及１４０例慢支合并肺气肿患者ＤＬＣＯ及常规肺功能。结果：男、女两性的ＤＬＣＯ与年龄、身高显著相关（Ｐ＜０．０１）。求出预计回归方程式，对各组ＤＬＣＯ实测值占预计值百分比均值进行了比较。哮喘组ＤＬＣＯ正常（Ｐ＞０．０５），肺通气功能明显减低（Ｐ＜０．０１）；肺间质性病变组ＤＬＣＯ明显减低（Ｐ＜０．０１），肺通气功能呈限制性障碍；慢支合并肺气肿患者ＤＬＣＯ及常规肺功能明显异常（Ｐ＜０．０１），ＤＬＣＯ随肺气肿加重而减低。结论：ＤＬＣＯ测定对哮喘、肺间质性病变及肺气肿严重程度的判断和疗效的考评具有一定的参考价值。
Objective: To investigate the normal value of DLCO and the regression equation and its clinical application in healthy adults. Methods: The DIO and routine pulmonary function of 175 healthy adults, 24 patients with bronchial asthma, 19 patients with interstitial lung disease and 140 patients with chronic bronchitis complicated with emphysema were measured by 6200 Autobox DL plethysmography. Results: DLCO was significantly correlated with age and height in male and female (P <0.01). The regression equation was obtained and the measured DLCO values in each group were compared with the predicted percentage average. The DLCO in asthma group was normal (P> 0.05) and the lung ventilation function was significantly reduced (P <0.01). The DLCO in pulmonary interstitial lesions was significantly lower (P <0.01) Dlco and conventional pulmonary function were significantly abnormal in patients with chronic bronchitis complicated with emphysema (P <0.01), and DLCO was decreased with the increase of emphysema. Conclusion: The determination of DLCO on asthma, interstitial lung disease and severity of emphysema to determine and evaluate the evaluation of a certain reference value.