论文部分内容阅读
心肌坏死伴有蛋白质变性和其抗原性改变。许多试验证明,心肌梗塞患者血循环中有心肌抗原。但是,检查心肌抗体的诊断价值不大,因为抗心肌抗体的检出率波动于25～100％之间,而且仅在心肌梗塞的第一周末才能检出循环抗体。近年证明,在抗原刺激免疫的过程中,至少涉及三个细胞系统:巨噬细胞、T-淋巴细胞和B-淋巴细胞。致敏供体的T-淋巴细胞在试管内受抗原刺激后将产生巨噬细胞移动抑制因子,其产生的多少与供体的致敏程度密切相关。因此,T-淋巴细胞产生这种因子的强度,是病人对某种抗原是否发生致敏和致敏程度的有价值的指标。本文报道用毛细血管法检测心肌梗塞病人抗心肌细胞膜抗原的白细胞移动抑制因子的结果。
Myocardial necrosis with protein degeneration and its antigenic changes. Many trials have shown that myocardial antigens in the circulation of patients with myocardial infarction. However, the diagnosis of myocardial antibodies is of little value because the detection rate of anti-myocardial antibodies fluctuates between 25% and 100%, and circulating antibodies can only be detected at the end of the first week of myocardial infarction. In recent years, it has been demonstrated that at least three cellular systems are involved in antigen-stimulated immunity: macrophages, T-lymphocytes and B-lymphocytes. Sensitized donor T-lymphocytes stimulated by antigen in the test tube will produce macrophage migration inhibitory factor, and its production is closely related to the degree of donor sensitization. Therefore, the intensity of this factor produced by T-lymphocytes is a valuable indicator of whether a patient is sensitized and sensitized to an antigen. This paper reports the results of the leukocyte migration inhibitory factor assaying antimyocardial membrane antigen in patients with myocardial infarction by capillary method.