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目的:探讨血清胱抑素C(Cyst C)在预测过敏性紫癜患儿肾脏早期损伤的作用.方法:选择2011年2月至2012年9月我院尿常规正常的 HSP 住院患儿102例(HSP组),其中男63例、女39例,平均年龄7.59±2.83岁.选择50名健康体检儿童作为对照组,其中男27名、女23名,平均年龄8.18±2.85岁.对所有研究对象测定血清 CysC 浓度、血尿素氮(blood urea nitrogen,BUN)浓度、血清肌酐(serum creatinine,SCr)浓度、内生肌酐清除率(Creatinine Clearance rate,CCr)(mL/min),患者入院时测定晨起空腹尿常规.结果:在发病4天对有肾脏早期损伤HSP组内血清胱抑素C增高,而且与对照组比较血清CysC差异有统计学意义(t=3.18, P 0.05).发病8天后 HSP 组与对照组比较,有肾脏损伤的患者血清 CysC 也明显增高,差异有统计学意义(t=4.18,P <0.05),血清 BUN(t=4.53)、Cr(t=3.65)、CCr(t=4.75)差异有统计学意义(P 均<0.05).结论:血清胱抑素 C 是一种稳定可靠的预测肾早期损害的指标.“,”Objective: To investigate the serum cystatin C (Cyst C) in the prediction of early renal damage in children with Henoch-Schonlein purpura role. Method: Select 102 hospitalized patients (HSP group), male 63 cases, female 39 cases, mean age 7.59± 2.83 years old. Select 50 healthy children as control group, male 27, female 23, mean age 8.18± 2.85 years old. For al the research object of serum CysC concentration, blood urea nitrogen ( blood urea nitrogen, BUN, serum creatinine ( serum ) concentration, creatinine concentration, SCr ), Creatinine Clearance rate. Determination of fasting urine routine to patients on admission. Results: Compared with the control group, In 4 days, on early renal damage in the HSP group, serum cystatin C increase and with significant difference (t=3.18,P0.05). Compared with the control group ,after 8 days of onset, renal injury in serum of patients with CysC were significantly higher in HSP group, with significant difference (t=4.18,P<0.05), serum BUN (t=4.53), Cr (t=3.65), CCr (t=4.75) with significant difference (P<0.05). Conclusion: serum cystatin C is a reliable prediction of early renal damage with Henoch-Schonlein purpura role.