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目的:比较舒芬太尼及盐酸纳布啡在胃十二指肠镜检查中的镇痛效果。方法:抽取2018年8月至2020年7月在南阳医学高等专科学校第一附属医院接受胃十二指肠镜检查的91例患者,按随机数字表法将其分为观察组46例和对照组45例。对照组应用舒芬太尼麻醉,观察组应用盐酸纳布啡麻醉。对比两组患者的生命体征指标、麻醉效果及不良反应发生情况。结果:进入检查室时、插入胃镜经过食管、胃镜经幽门进入十二指肠、检查后睁眼时,两组患者呼吸频率、心率、平均动脉压、血氧饱和度比较差异均未见统计学意义(n P均>0.05),且麻醉诱导时间、苏醒时间及视觉模拟评分法(VAS)评分、Ramsay评分比较差异均未见统计学意义(n P均>0.05)。术后,观察组不良反应率为4.44%(2/46),对照组为17.39%(8/45),差异有统计学意义(n P0.05. There was no significant difference in anesthesia induction time, recovery time, visual analogue scale score, or Ramsay score between the two groups (alln P>0.05). After operation, the incidence of adverse reaction of the observation group was 4.44% (2/46), significantly lower than the 17.39% (8/45) of the control group (n P<0.05).n Conclusions:The application of sufentanil and nalbuphine hydrochloride in gastroduodenal endoscopy have similar analgesic and sedative effects, and they has comparable effects on vital signs, both of which can meet the needs of examinations. But the adverse reactions of nalbuphine hydrochloride are less.