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目的探讨血清TNF-α、IL-8的水平与肝硬化的关系。方法采用ELISA法检测肝硬化患者血清TNF-α、IL-8水平,根据Child分级将42例肝硬化患者分为A(12例)、B(23例)、C(7例)3组,并与正常组(29例)相对照。结果肝硬化组血清TNF-α、IL-8水平较正常组明显升高(P<0.01),A、B、C三组各项指标比较差异显著(P<0.01)。结论血清TNF-α、IL-8水平是反映肝硬化程度的重要指标。
Objective To investigate the relationship between serum levels of TNF-α and IL-8 and cirrhosis. Methods Serum levels of TNF-α and IL-8 in patients with cirrhosis were detected by ELISA. According to Child classification, 42 patients with cirrhosis were divided into A (12 cases), B (23 cases) and C (7 cases) Compared with the normal group (29 cases). Results The levels of serum TNF-α and IL-8 in cirrhosis group were significantly higher than those in normal group (P <0.01). The indexes of A, B and C groups were significantly different (P <0.01). Conclusion Serum TNF-α and IL-8 levels are important indicators of the degree of cirrhosis.