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[目的]观察远隔缺血时处理对体外循环（C PB ）瓣膜置换术患者尿中性粒细胞明胶酶相关性脂质运载蛋白（NGAL）和肾损伤分子1（KIM-1）的影响。[方法]择期CPB下瓣膜置换术患者60例，随机分为两组（ n＝30）：远隔缺血时处理组（R组）和对照组（C组）。R组在主动脉阻断同时对患者右下肢实施3周期5 min缺血/5 min再灌注处理；C组不进行该处理。分别于术前（T0）、CPB结束后2 h（T1）、6 h（T2）、12 h（T3）、24 h（T4）和48 h（T5）6个时间点检测尿NGAL、KIM-1和血肌酐（SCr）的水平，记录各时间段尿量。[结果]与C组相比，R组尿NGAL在T1、T2、T3、T4较低，KIM-1在 T2、T3、T4较低，尿量在 T1～2，T2～3时间段较多（ P ＜0．05）；与 T0相比，两组患者尿NGAL在T1～T4明显升高，KIM-1在T2～T5明显升高，SCr在T5明显升高（ P ＜0．05）。[结论]远隔缺血时处理可降低瓣膜置换术患者尿 NGAL和KIM-1的水平，对CPB后肾损伤有一定的保护作用。“,”[Objective] To observe the effect of remote ischemic preconditioning on urinary neutrophil gelatinase-asso-ciated lipocalin(NGAL) and kidney injury molecule-1(KIM-1) in patients undergoing valve replacement surgery with car-diopulmonary bypass(CPB) .[Methods] Totally 60 patients scheduled for valve replacement with CPB were randomly di-vided into remote ischemic preconditioning (group R ,n=30) and control group(group C .n=30) .Group R received aortic occlusion and 3 cycles of 5-min ischemia and 5-min reperfusion conditioning on right lower limb ,while group C did not re-ceived the treatment .NGAL and KIM-1 in urine and serum creatinine(SCr) were detected before surgery(T0 ) ,2h(T1 ) , 6h(T2 ) ,12h(T3 ) ,24h(T4 ) and 48h(T5 ) after CPB ending point .Urine volume was recorded at each time point .[Results]Compared with group C ,urine NGAL at T1 ,T2 ,T3 ,and T4 were lower ,and KIM-1 at T2 ,T3 and T4 were lower ,and urine volume at T1~2 and T2~3 were larger in group R( P<0 .05) .Compared with T0 ,urine NGAL at T1 ~T5 ,KIM-1 at T3 ~T5 and SCr at T5 were obviously increased in two groups ( P<0 .05) .[Conclusion]Remote ischemic perconditioning can reduce the levels of urine NGAL and KIM-1 in patients undergoing valve replacement with CPB ,and has certain protective effect on kidney injury after CPB .