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治疗儿童急性中耳炎所选择的抗菌剂必须有抗肺炎链球菌和流感嗜血杆菌的活性。A组链球菌和金黄色葡萄球菌不是急性中耳炎的常见病因,所以在制定初步的治疗方案时,不必考虑在内。当新生儿和免疫应答被抑制及有慢性中耳炎化脓并发症的病人发生中耳炎时,必须考虑到革兰氏阴性肠道杆菌。在中耳液中,能发现高浓度的大多数治疗中耳炎有效的抗菌素。给药后,在中耳液中迅速产生抗菌活性,维持时间约与在血清中的时间相同。
Antimicrobial agents selected for the treatment of acute otitis media in children must have activity against S. pneumoniae and H. influenzae. Group A streptococci and Staphylococcus aureus is not a common cause of acute otitis media, so in the development of the initial treatment options, do not have to consider. Gram-negative enterobacteria must be considered when neonates and otitis media are suppressed in patients with suppurative complications of chronic otitis media. In the middle ear fluid, high concentrations of most effective antimicrobials for otitis media can be found. After administration, antibacterial activity was rapidly developed in the middle ear fluid for about the same time as in serum.