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当口服抗原时,抗原如何刺激IgA抗体呢?这可能与调节IgA应答的T淋巴细胞的特殊解剖分布有关。在研究IgM、IgG和IgE应答时,证实T细胞调节抗体生成(有些是辅助,有些是抑制)的概念。发现刀豆素A(ConA)在致有丝分裂浓度时可刺激T细胞抑制IgM和IgG合成。Elson等报导ConA能刺激小
How do antigens stimulate IgA antibodies when orally administered? This may be due to the specific anatomic distribution of T lymphocytes that regulate IgA responses. When studying IgM, IgG and IgE responses, the concept that T cells modulate antibody production (some are helper and some are inhibitory) is demonstrated. ConA was found to stimulate T cells to inhibit IgM and IgG synthesis at mitogenic concentrations. Elson et al reported that ConA can stimulate small