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1981年,Vale从羊的下丘脑提纯出一种激素,因此激素控制着促肾上腺皮质激素(adrenocorticotropic hormone,ACTH)的释放,调节下丘脑-垂体-肾上腺(hypothalamic-pituitary-adrenal,HPA)轴对应激的反应,故命名为促肾上腺皮质激素释放激素(corticortropin-releasing hormone,CRH)。以后的研究表明CRH不仅在脑组织中广泛分布,也可来源于外周组织及人的胎儿胎盘单位。现已证明人类胎盘中有CRH、CRH受体(CRH-receptor,CRH-R)、CRH结合蛋白(CRH-binding protein,CRHBP)及CRH信使RNA(CRHmRNA)的表达。 CRH为41个氨基酸的肽类,分子量4 670,基因定位于第8号染色体的长臂上,由2个外显子和1
In 1981, Vale purified a hormone from the hypothalamus of sheep so that hormones control the release of adrenocorticotropic hormone (ACTH) and regulate the hypothalamic-pituitary-adrenal (HPA) axis response Excited response, so named corticotrophin releasing hormone (corticortropin-releasing hormone, CRH). Subsequent studies have shown that CRH is not only widely distributed in brain tissue, but also derived from peripheral tissues and human fetal placenta. It has been demonstrated that the expression of CRH, CRH receptor, CRH-binding protein (CRHBP) and CRH mRNA (CRHmRNA) are present in human placenta. CRH is a 41 amino acid peptide with a molecular weight of 4670. The gene is located on the long arm of chromosome 8 and consists of two exons and one