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多巴(DOPA)作为一种生物配体,由于其独特的生物粘附性在近来的研究中受到广泛关注。本研究中将DOPA分子和二硫键修饰于四臂聚乙二醇分子(T-PEG)的末端,利用高碘酸钠(NaIO4)实现其快速交联,得到了水凝胶。研究表明,该水凝胶在不同浓度的谷胱甘肽(GSH)作用下可实现在不同时间的降解,DOPA分子的引入显著提高了该水凝胶的机械强度。3D细胞培养及毒性测试表明,该水凝胶对骨髓间质干细胞(BMSCs)的生长有较好的促进作用。
Dopa (DOPA) as a biological ligand, due to its unique bioadhesion in recent research has received widespread attention. In this study, DOPA molecules and disulfide bonds were modified at the ends of four-arm polyethylene glycol molecules (T-PEG), and the hydrogels were obtained by sodium periodate (NaIO4). Studies have shown that the hydrogels can be degraded at different times under the action of different concentrations of glutathione (GSH), and the introduction of DOPA molecules significantly improves the mechanical strength of the hydrogels. 3D cell culture and toxicity test showed that the hydrogel can promote the growth of bone marrow mesenchymal stem cells (BMSCs).