两种自家免疫性甲低患者治疗前后血清TSII、TGII及外周血T淋巴细胞亚群的变化

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对9例原发性粘液性水肿和14例Hashimoto甲状腺炎患者测定了血清TSII、TGII及外周血T淋巴细胞亚群,并以32例正常人作为对照.原发性粘液性水肿和Hashimoto甲状腺炎患者血清存在TSII、TGII,阳性比例不同,而且外周血CD8+百分率降低和CD4+/CD8+比值增高.TSII、TGII活性与CD4+/CD8+比值无显著相关.经甲状腺激素治疗,两种自家免疫性甲低患者甲状腺功能明显恢复,血清TSII、TGII活性无明显变化,原发性粘液性水肿患者外周血T淋巴细胞亚群未见明显变化,而Hashimoto甲状腺炎患者CD8+百分率明显回升. Serum TSII, TGII and peripheral blood T lymphocyte subsets were measured in 9 patients with primary myxedema and 14 with Hashimoto’s thyroiditis, and 32 healthy controls were used as controls. TSII and TGII are present in serum of patients with primary myxedema and Hashimoto’s thyroiditis, with different percentages of CD8 + and CD4 + / CD8 + in peripheral blood. TSII, TGII activity and CD4 / CD8 ratio no significant correlation. Thyroid hormone therapy, thyroid function in two patients with a self-immune hypothyroidism was significantly restored, serum TSII, TGII activity no significant change in patients with primary myxedema in peripheral blood T lymphocyte subsets no significant changes, and Hashimoto thyroiditis The percentage of patients with CD8 increased significantly.
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