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目的探讨单唾液酸四己糖神经节苷脂治疗脑出血的疗效与安全性。方法根据治疗方案将2010年3月—2013年12月我院收治的137例脑出血患者分为观察组与对照组,观察组患者72例,在常规治疗基础上联合使用单唾液酸四己糖神经节苷脂,对照组患者65例,在常规治疗基础上联合使用胞二磷胆碱治疗,现对比分析两组患者的疗效。结果 1治疗前,两组患者NHISS评分、mRS评分、血肿体积相比差异无统计学意义(P>0.05);治疗第21d,观察组NHISS评分、mRS评分、血肿体积显著低于对照组,差异有统计学意义(P<0.05)。2观察组病死率、住院时间显著低于对照组,差异有统计学意义(P<0.05)。3两组患者不良反应发生率相比差异无统计学意义(P>0.05)。结论单唾液酸四己糖神经节苷脂治疗脑出血既可以改善患者神经功能缺损情况,还可以降低病死率、缩短住院时间,且安全可靠。
Objective To investigate the efficacy and safety of monosialotetrahexosyl gangliosides in the treatment of intracerebral hemorrhage. Methods According to the treatment plan, 137 patients with cerebral hemorrhage treated in our hospital from March 2010 to December 2013 were divided into observation group and control group, 72 patients in observation group were treated with monosialotetrahexose Ganglioside, 65 patients in the control group, on the basis of conventional treatment combined with citicoline treatment, the efficacy of the two groups were compared. Results Before treatment, there was no significant difference in NHISS score, mRS score and hematoma volume between the two groups (P> 0.05). On the 21st day after treatment, NHISS score, mRS score and hematoma volume in the observation group were significantly lower than those in the control group There was statistical significance (P <0.05). 2 The mortality and hospital stay in the observation group were significantly lower than those in the control group (P <0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P> 0.05). Conclusion Monosialotetrahexosyl gangliosides treatment of cerebral hemorrhage can improve neurological deficit in patients, but also reduce mortality and shorten the hospital stay, and safe and reliable.