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观察通脉降脂对AS患者血清中肿瘤坏死因子 -α(TNF -α)、白细胞介素 -6(IL -6)及血管性假血友病因子 (vWF)水平的影响 ,探讨炎症反应在AS病变发生、发展中的作用 ,并初步验证降脂通脉的疗效。研究证实通脉降脂可显著降低血清TC、LDL -C和apoB -10 0 ,升高HDL -C ,且经通脉降脂治疗后vWF、TNF-α和IL -6在血清中的水平显著低于治疗前 ,说明通脉降脂通过其良好的调节血脂的疗效而对内皮细胞有保护作用 ,进一步深入研究细胞因子TNF -α和IL -6在AS发生发展中的作用 ,对AS心脑并发症的预防性检测以及AS的防治均具有十分重要的临床意义。通脉降脂作为一种纯中药制剂 ,具有更加安全可靠、且价格低廉等优点。总之 ,进一步深入研究细胞因子TNF -α和IL -6在AS发生发展中的作用 ,对AS心脑并发症的预防性检测以及AS的防治均具有十分重要的临床意义。
To observe the effects of Tongmai and lipid-lowering on serum levels of tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), and von Willebrand factor (vWF) in AS patients The role of AS lesions, development, and preliminary validation of the efficacy of lipid-lowering Tongmai. The study confirmed that Tongmai and lipid-lowering can significantly reduce serum TC, LDL-C and apoB-10, increase HDL-C, and the levels of vWF, TNF-α and IL-6 in serum after Tongmai and lipid-lowering therapy are significant. Before treatment, it was demonstrated that Tongmai and lipid-lowering had protective effects on endothelial cells through its good regulation of blood lipids, and further studies of the role of cytokines TNF-α and IL-6 in the development of AS were performed. Preventive detection of complications and prevention of AS all have very important clinical significance. Tongmai lipid-lowering as a pure Chinese medicine preparation, has the advantages of more safety, reliability, and low price. In conclusion, further study of the role of cytokines TNF-α and IL-6 in the development of AS plays an important role in the prophylactic detection of AS-related cardio-cerebral complications and the prevention and treatment of AS.