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目的探讨骨髓细胞学检查在视网膜母细胞瘤转移中的应用价值。方法选取2008年1月至2009年4月临床确诊为视网膜母细胞瘤的211例患儿,在治疗前常规进行骨髓穿刺,并行骨髓细胞学检查,观察早期有无骨髓转移。结果在211例患儿中210例为正常骨髓象,1例骨髓中发现有肿瘤细胞,但不能确定是视网膜母细胞瘤肿瘤细胞。结论视网膜母细胞瘤早期骨髓转移发生率极低,入院患者是否应当常规做骨髓细胞学检查值得商榷。但骨髓细胞学检查仍然是早期发现转移的重要手段之一,对于存在高风险转移因素的患儿仍应积极进行此项检查。
Objective To investigate the value of bone marrow cytology in the metastasis of retinoblastoma. Methods Totally 211 children with retinoblastoma diagnosed as retinoblastoma from January 2008 to April 2009 were selected. Bone marrow aspiration and bone marrow cytology were performed before treatment to observe the early stage of bone marrow metastasis. RESULTS: Of the 211 children, 210 were normal bone marrow and 1 were found in the bone marrow, but were undetermined as retinoblastoma tumor cells. Conclusion The incidence of early bone marrow metastasis of retinoblastoma is very low. It is debatable whether routine marrow biopsy should be performed in hospitalized patients. However, bone marrow cytology is still an important means of early detection of metastasis, which should be actively performed in children with high-risk metastasis.