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目的:通过检测膀胱肿瘤相关抗原(BTAA)在中国人群中膀胱尿路上皮癌诊断中的敏感性及特异性,从而为早期诊断及术后随访提供更准确、更无创的诊断方式。方法:收集江苏省肿瘤医院泌尿外科病例301例,其中试验组105例,经膀胱镜活检病理确诊为膀胱尿路上皮癌;对照组为正常参加医院体检且结果提示正常的健康人群和经影像学检查或膀胱镜检查均为非膀胱尿路上皮癌患者的住院人群,共196例。检测尿液标本中BTAA含量。结果:以膀胱镜活检病理确诊为金标准检测结果,采用BTAA定量测定阳性率,阴性率分别为81.9%,88.3%。以病理恶性程度分层,低度恶性潜能尿路上皮乳头状瘤、低级别、高级别尿路上皮癌阳性率分别为58.6%、88.9%、92.5%。结论:膀胱肿瘤相关抗原是一种灵敏度强,特异性高,并且便于群体性筛查的无创性检查。有利于膀胱癌的早期诊断,对预后以及检测复发都具有重要的意义。
Objective: To provide a more accurate and noninvasive diagnostic method for early diagnosis and postoperative follow-up by detecting the sensitivity and specificity of bladder cancer-associated antigen (BTAA) in the diagnosis of bladder urothelial carcinoma in Chinese population. Methods: Totally 301 urological cases were collected from the Tumor Hospital of Jiangsu Province, including 105 cases in the experimental group, which were diagnosed as bladder urothelial carcinoma by cystoscopy biopsy. In the control group, the normal healthy group and the normal healthy group Examination or cystoscopy are non-bladder urinary tract cancer patients inpatients, a total of 196 cases. Detection of urine samples BTAA content. Results: The results of gold biopsy were confirmed by cystoscopy biopsy. The positive rates of BTAA were 81.9% and 88.3%, respectively. The positive rates of urothelial carcinoma, low grade and high grade urothelial carcinoma were 58.6%, 88.9% and 92.5%, respectively. Conclusion: Bladder tumor-associated antigen is a non-invasive examination with strong sensitivity, high specificity and easy mass screening. Is conducive to the early diagnosis of bladder cancer, prognosis and detection of recurrence is of great significance.