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目的 :探讨难治性急性非淋巴细胞白血病 (ANL L)的治疗。方法 :11例难治性 ANL L 用 MAC联合环孢霉素 A(Cs A)方案治疗。用法 :Cs A(8m g.kg- 1 .d- 1 ,第 1天～第 3天 ;4m g.kg- 1 .d- 1 ,第 4天～第 5天 )口服 ;MTZ10mg/ d,第 1天～第 3天 ,静滴 ;Ara- C15 0 m g/ d,第 1天～第 7天静滴 ;CTX6 0 0 mg/ d,第 2、4天静滴。结果 :完全缓解率为5 5 .6 % ,部分缓解率为 18.2 % ,总有效率 72 .7%。结论 :MAC联合 Cs A方案治疗难治性 ANL L 是有效的。
Objective: To investigate the treatment of refractory acute lymphoblastic leukemia (ANL L). Methods: 11 refractory ANL L were treated with MAC combined with cyclosporin A (Cs A) regimen. Usage: Cs A (8m g.kg-1.d-1, Day 1 to Day 3; 4m g.kg-1.d-1, Day 4 to Day 5) Orally; MTZ 10mg/day, Section On days 1 to 3, intravenous infusions; Ara-C15 0 mg/day, intravenous infusion from day 1 to day 7; CTX6 0 mg/day, intravenous infusion on days 2 and 4. Results: The complete remission rate was 55.6%, the partial remission rate was 18.2%, and the total effective rate was 72.7%. Conclusion : MAC combined with Cs A regimen is effective for the treatment of refractory ANL L.