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豚鼠离体气管片经利尿酸(50μg/ml)孵育1小时后,对硝普钠的反应性显著降低(P<0.05,n=4);豚鼠气管纵行平滑肌用氯化汞(50μg/ml)孵育后,组织中可测定的-SH 基含量显著减少(P<0.01,n=4),同时,硝普钠松弛气管平滑肌的作用也几乎完全消失,而加入1:1000二巯基丁二酸钠,又可使氯化汞对硝普钠的抑制作用逆转,表明硝普钠松弛气管平滑肌的作用与组织中的-SH 基有关。本文讨论了硝普钠与组织中-SH 结合后引起平滑肌松弛作用机制的二种假设。
The reactivity of sodium nitroprusside (P <0.05, n = 4) was significantly lower in guinea pig tracheal strips incubated with nicotinic acid (50μg / ml) for 1 hour. Guinea pig tracheal longitudinal smooth muscle was treated with mercuric chloride ), The measurable content of -SH in the tissue was significantly decreased (P <0.01, n = 4). At the same time, the effect of sodium nitroprusside on tracheal smooth muscle relaxation almost completely disappeared, while the addition of 1: 1000 dimercaptosuccinic acid Sodium, but also make mercuric chloride on the inhibitory effect of sodium nitroprusside reversed, indicating that sodium nitroprusside relaxes the role of the tracheal smooth muscle tissue and the-SH-related. This article discusses two hypotheses of the mechanism by which sodium nitroprusside causes smooth muscle relaxation following binding of -SH in tissues.