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给Ｗｉｓｔａｒ大鼠连续６０ｄ口服甲状腺素片（每只４ｍｇ／ｄ），使大鼠处于高甲状腺激素状态，然后检测其心肌微粒体几种ＡＴＰ酶活性。结果：实验组大鼠出现甲亢体征，Ｎａ＋，Ｋ＋－ＡＴＰ酶，Ｃａ２＋－ＡＴＰ酶活性分别为７．６±１．３和１６．５±１．８μｍｏｌＰｉ·ｇＨｂ－１·ｈ－１，均明显低于对照组（Ｐ＜０．０１），Ｍｇ２＋－ＡＴＰ酶活性为３５．３±２．５μｍｏｌＰｉ·ｇＨｂ－１·ｈ－１，明显高于对照组（Ｐ＜０．０１）。上述结果表明，甲亢时心肌微粒体Ｎａ＋，Ｋ＋泵和Ｃａ２＋泵功能发生了改变，心肌细胞钙代谢失常。
The Wistar rats were orally administered with thyroxine tablets (4 mg / d each) for 60 consecutive days. The rats were subjected to high thyroid hormone status and then tested for several ATPase activities in their myocardial microsomes. Results: The signs of hyperthyroidism were observed in experimental group, and the activities of Na +, K + -ATPase and Ca2 + -ATPase were 7.6 ± 1.3 and 16.5 ± 1.8μmolPi · gHb-1 · h-1 respectively (P <0.01). The activity of Mg2 + -ATPase was 35.3 ± 2.5μmolPi · gHb-1 · h-1, which was significantly higher than that of the control group (P <0.01). The above results show that hyperthyroidism myocardial microsomal Na +, K + pump and Ca2 + pump function has changed, myocardial cell calcium metabolism disorders.