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应用放射免疫方法测定了27例哮喘发作、18例哮喘缓解状态患者血浆内皮素浓度,并与42例正常人进行比较。结果表明,哮喘发作患者血浆内皮素浓度明显高于正常人及哮喘缓解状态者(P值分别为P<0.01与P<0.05),而哮喘缓解组与正常对照组间无显著性差异(P>0.05)。提示血浆内皮素浓度与哮喘发作有关,可能是哮喘发作的中间介质。
Radioimmunoassay method was used to determine the plasma endothelin concentration in 27 asthmatic patients and 18 asthmatic patients with remission and compared with 42 normal controls. The results showed that the plasma endothelin concentration in patients with asthma attack was significantly higher than that in normal people and asthma relief patients (P <0.01 and P <0.05, respectively), but there was no significant difference between asthma remission group and normal control group Difference (P> 0.05). Tip plasma endothelin concentration and asthma attack, may be the intermediate mediator of asthma attacks.