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Clark等及新近其他研究人员表明,子宫单核细胞群对正常胚胎着床似有重要作用。IUD抗生育作用的主要特点为阻碍胚胎着床。置器子宫的组织学研究多次表明,内嵌的IUD周围有异常细胞浸润,常称之为“无菌炎性浸润”。放置IUD时,子宫特异细胞群与IUD的抗生育作用是否有关,目前尚不明确。本研究报道了放置IUD、宫腔单核细胞群增加和IUD碎片的抗生育效果三者之间的相关作用。材料和方法所有试验均采用6～8周龄B6D2F1/HSD或ICR小鼠,150只小鼠等分为三组。于
Clark et al. And other recent researchers have shown that uterine monocyte populations play an important role in normal embryo implantation. The main feature of IUD’s resistance to fertility is hindering embryo implantation. Histology of the uterus has repeatedly shown that there are abnormal cell infiltrates around the embedded IUD, often referred to as “sterile inflammatory infiltrates.” It is not yet clear whether the uterine-specific cell population is associated with the anti-fertility effects of IUD when IUD is placed. This study reports the correlation between placement of IUDs, increased uterine mononuclear cell population, and anti-fertility effects of IUD fragments. MATERIALS AND METHODS All experiments were performed on 6 to 8 weeks old B6D2F1 / HSD or ICR mice and 150 mice equally divided into three groups. in