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目的研究伴有双侧海马硬化颞叶癫痫患者的脑功能活动。资料与方法7例颞叶癫痫患者,均为双侧海马硬化,其中男6例,女1例,平均年龄16.7岁。单纯部分性发作者4例、部分继发全面发作者3例。7例患者均接受了脑电功能磁共振同步联合检查。结果5例患者内侧颞叶有明显激活,2例颞叶激活区位于新皮层中;边缘系统和皮层下结构有较明显的激活;大脑皮层中的激活区主要位于中央区。组分析结果显示,负激活的脑区与经典的脑缺省模式脑区一致。结论内侧颞叶硬化与颞叶癫痫之间关系紧密,边缘系统和皮层下结构参与痫样放电的易化和传播,长期的异常放电会对癫痫患者的脑功能活动产生影响。
Objective To investigate brain function in patients with bilateral temporal hippocampal epilepsy. Materials and Methods 7 cases of temporal lobe epilepsy patients, bilateral hippocampal sclerosis, including 6 males and 1 females, with an average age of 16.7 years. Simple partial onset in 4 cases, in part secondary to full attack in 3 cases. All 7 patients underwent simultaneous EEG magnetic resonance imaging. Results The medial temporal lobe was significantly activated in 5 patients. Two temporal lobe activation regions were located in the neocortex. The limbic system and subepithelial structures were significantly activated. The activation region in the cerebral cortex was mainly located in the central region. Group analysis showed that the area of negatively activated brain was consistent with that of the classical brain default mode. Conclusions The relationship between medial temporal lobe sclerosis and temporal lobe epilepsy is closely related. The limbic system and subcortical structures are involved in the facilitation and dissemination of epileptiform discharges. Long-term abnormal discharge may have an impact on brain function in patients with epilepsy.